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Updated: Jun 18, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
10:44

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures

Published on: March 28, 2017

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肝脏和第一通路CYP3A活动的静脉和口腔试验中的内主体变异性

Evan D Kharasch1,2, Christine Hoffer3, Pamela Bedynek3

  • 1Department of Anesthesiology, Duke University School of Medicine, 905 S. LaSalle St, GSRB1 Room 2031, Box 3094, Durham, NC, 27710, USA. evan.kharasch@duke.edu.

Clinical pharmacokinetics
|July 29, 2024
PubMed
概括

米达佐拉姆和阿尔芬坦尼尔对细胞染色体P450 3A (CYP3A) 活性探针具有相似的个体内变异性. 一次性血度的变化比曲线下的面积 (AUC) 和清除度量更高.

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