金属暴露与HPV感染之间的关系:可解释的机器学习方法的证据
Huangyu Hu1,2, Yue Wu3, Jiaqi Liu1,2
1Acupuncture School of Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Biological trace element research
|July 29, 2024
概括
接触金属,特别是 (Pb),可能会增加人类乳头瘤病毒 (HPV) 感染风险,而 (Co) 则显示出相反的关联. 联合金属暴露也与更高的HPV流行率相关,突出了HPV感染风险的环境因素.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 人类乳头瘤病毒 (HPV) 是全球宫癌和其他癌症的主要原因之一.
- 现有的HPV疫苗并不涵盖所有致癌亚型.
- 金属暴露在HPV感染风险和进展中的作用尚未得到充分研究.
研究的目的:
- 调查单个和混合金属暴露与HPV感染之间的关联.
- 评估金属暴露对HPV感染流行率的贡献.
主要方法:
- 从2007-2016年国家健康和营养检查调查 (NHANES) 中对2765名妇女进行横截面分析.
- 单个金属暴露的多变量逻辑回归 ([Co],[Pb]).
- 混合金属暴露的权重定量总和 (WQS) 回归.混合金属暴露.
- XGBoost + SHapley 添加式扩展 (SHAP) 对于特征的重要性.
主要成果:
- 增加的Pb度与增加的HPV感染有关 (OR 1.176).
- 升高的Co度与HPV感染相反相关 (OR 0.891).
- 组合金属暴露 (WQS指数) 显示出与HPV感染的积极关联 (OR 1.249).
- SHAP分析确定性伴侣数量,婚姻状况,PIR,Co,Pb和酒精消费是关键因素.
结论:
- 暴露与更高的HPV感染率有关,而暴露显示出保护作用.
- 对多种金属的累积暴露可能会增加HPV感染的流行率.
- 环境金属暴露是影响HPV感染风险的潜在因素.
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