孕产妇的肥胖和婴儿突然意外死亡的风险
Darren Tanner1, Jan-Marino Ramirez2,3,4, William B Weeks1
1AI for Good Research Lab, Microsoft Corporation, Redmond, Washington.
JAMA pediatrics
|July 29, 2024
概括
孕产妇的肥胖增加了婴儿突然意外死亡 (SUID) 的风险. 这项研究发现了一种剂量依赖的关系,严重肥胖症构成最高风险,占SUID病例的5.4%.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 儿科 儿科 儿科
背景情况:
- 在美国,孕产妇肥胖率正在上升.
- 肥胖与不良妊娠结果有关,但尚未被认为是SUID风险因素.
研究的目的:
- 确定母亲的肥胖是否是SUD的危险因素.
- 量化与母亲肥胖相关的SUID病例的比例.
主要方法:
- 美国全国的队列研究 (2015-2019) 使用链接的出生-婴儿死亡记录.
- 分析了超过1880万活产儿,根据ICD-10代码识别了SUID病例.
- 孕前母亲的体重指数 (BMI) 是主要的暴露变量.
主要成果:
- 患有肥胖母亲的婴儿有更高的SUID风险,随着肥胖的严重程度而增加.
- 一级,二级和三级肥胖与调整后的几率比分分别为1.10,1.20和1.39有关.
- 大约5.4%的SUID病例归因于母亲的肥胖.
结论:
- 孕产妇的肥胖是SUD的一个重要风险因素.
- 在母亲的BMI和SUID风险之间存在剂量依赖的关联.
- 需要进一步的研究来探索因果机制.
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