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儿童虐待和长度表观遗传衰老:NIMHD社会表观遗传学计划

Olivia D Chang^1,2, Helen C S Meier³, Kathryn Maguire-Jack¹

¹School of Social Work, University of Michigan, Ann Arbor.

JAMA network open

|July 29, 2024

概括

童年虐待,包括身体攻击和情感忽视,与表观遗传衰老特征有关. 这些影响很早就出现并持续存在,表明早期生活经历中压力的生物嵌入.

科学领域:

表观遗传学和发育心理学
分子流行病学分子流行病学
童年创伤研究童年创伤研究

背景情况:

童年虐待,包括身体和情感虐待和忽视,可能会留下与加速衰老相关的长期表观遗传痕迹.
了解早期生命逆境对生物衰老的长期影响对于公共卫生至关重要.

研究的目的:

调查早期和中期儿童虐待暴露与儿童和青少年晚年加速衰老的表观遗传标记之间的纵向关联.
为了确定虐待的类型和时间是否会影响表观遗传衰老特征.

主要方法:

利用了来自未来家庭和儿童福利研究的数据,这是美国出生队列.
评估了9岁和15岁的DNA甲基化 (DNAm) 数据,以及从出生到15岁的表型数据.
使用机器学习替代品 (GrimAge,PhenoAge,DunedinPACE,Horvath,PedBE) 测量了表观遗传加速衰老 (DNAmAA),并分析了3岁和5岁的身体攻击和情绪攻击等暴露.

主要成果:

3岁时的身体攻击与PhenoAge DNAmAA的增加有关;情绪上的攻击与PhenoAge DNAmAA的减少有关.
5岁时的情感疏忽与增加的PhenOAge DNAmAA有关.
累积虐待也表现出类似的关联,15岁时的效应与9岁时的DNAmAA.AA. 经过调整后,PhenoAge的关联仍然很重要.

结论:

表观遗传加速衰老模式对儿童虐待的特定类型和时间敏感.
研究结果表明,与虐待相关的压力存在生物学嵌入,可以通过表观遗传修饰来检测.
生命早期的逆境对生物衰老过程有明显的长期影响.

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