亲人的家庭丧失和生物衰老:NIMHD社会表观遗传学计划
Allison E Aiello1,2, Aura Ankita Mishra3, Chantel L Martin4,5
1Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
JAMA network open
|July 29, 2024
概括
从童年到成年时经历多次家庭损失与加速的生物衰老有关,特别是在中年之前. 这一发现可能有助于解释不同人群中的健康差异.
科学领域:
- 老年学是指老年学的学科.
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 家庭丧失是一个重要的生命事件,但其对健康的长期影响,特别是对生物衰老的影响,尚未完全理解.
- 之前的研究还没有全面研究各种类型的家族损失在整个寿命和生物衰老的客观措施之间的联系.
研究的目的:
- 研究经历父母,兄弟姐妹,孩子或伴侣/配偶的丧失与加速生物衰老之间的关联.
- 探索这些关联跨越不同的生命阶段,从童年到成年.
主要方法:
- 从青少年到成人健康国家纵向研究 (美国基于人口的队列研究) 的数据分析.
- 参与者报告了在24年内收集的损失 (第1-5波) 和从血液样本中进行的DNA甲基化测试.
- 使用多个表观遗传钟 (Horvath,PhenoAge,GrimAge,DunedinPACE) 进行评估的生物衰老.
主要成果:
- 近40%的参与者经历了损失,在黑人,西班牙裔和美洲印第安人中比例更高.
- 经历两次或更多的损失与根据PhenoAge,GrimAge和DunedinPACE时钟加速的生物衰老有关.
- 在多次损失和Horvath时钟之间没有发现显著的关联.
结论:
- 家庭损失,甚至在生命早期经历,与加速的生物衰老有关.
- 这些发现突显了损失对健康轨迹的持久影响,并可能有助于理解健康差异.
- 该研究强调了在健康和衰老的背景下考虑累积损失的重要性.
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