表观遗传衰老和种族,经济和环境不公正:NIMHD社会表观遗传学计划
Nancy Krieger1, Christian Testa1, Jarvis T Chen1
1Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
JAMA network open
|July 29, 2024
概括
与社会和经济不公正相关的表观遗传加速衰老可能会增加过早死亡的风险. 这项研究发现了表观遗传衰老与种族化,经济因素之间的关联,这表明健康差异的生物学机制.
科学领域:
- 遗传学和表观遗传学
- 公共卫生 公共卫生
- 社会流行病学 社会流行病学
背景情况:
- 表观遗传衰老加速与逆境有关,可能会增加发病和死亡风险.
- 之前的研究没有包括结构性种族主义措施,也没有比较不同的表观遗传时钟世代.
研究的目的:
- 调查表观遗传衰老加速与种族,经济和环境不公正的各种措施之间的关联.
- 通过不同层次和时间段来研究这些协会.
主要方法:
- 使用"我的身体我的故事" (MBMS) 和"多民族动脉样硬化研究" (MESA) 的数据进行横截面研究.
- 利用十个表观遗传钟 (6个第一代,4个第二代) 来计算DNA甲基化数据.
- 分析了美国出生的参与者的数据,包括非西班牙裔黑人,非西班牙裔白人和西班牙裔个人.
主要成果:
- 在非西班牙裔黑人MBMS参与者中,表观遗传年龄加速与出生在吉姆·克劳国家和出生状态保守主义有关.
- 较低的父母教育水平与黑人非西班牙裔和白人非西班牙裔MBMS参与者的表观遗传年龄加速相关.
- 在MESA参与者中,成年人的贫困与第二代表观遗传时钟在种族/种族群体之间显示出积极的关联.
结论:
- 表观遗传年龄加速与种族化和经济不公正有关,这可能解释健康不平等和过早死亡.
- 研究结果表明,表观遗传加速衰老可能是健康差异背后的一个生物学机制.
- 需要进一步的研究来证实这一假设及其对公共卫生干预措施的影响.
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