需要心脏手术的感染性内心炎患者的性别差异:来自CAMPAIGN研究小组的见解
Paula Ackermann1, Mateo Marin-Cuartas1, Carolyn Weber2
1University Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.
概括
虽然男性更经常接受感染性内心炎 (IE) 的手术,但女性面临更高的手术风险和更差的中期存活率. 这突显了IE患者结果的性别特异性差异.
科学领域:
- 心脏病学 心脏病学
- 心脏外科手术 心脏外科手术
- 传染性内心炎研究 传染性内心炎研究
背景情况:
- 与性别相关的差异影响心血管疾病的结果.
- 关于手术治疗感染性内心炎 (IE) 的性别差异存在知识差距.
研究的目的:
- 分析需要手术的IE患者临床表现,治疗和结果的性别特异性差异.
- 调查IE心脏手术后30天死亡率和中期存活率的性别相关变化.
主要方法:
- 在德国六个中心对4917名接受心脏手术的IE患者 (1994-2018) 进行了回顾性分析.
- 女性和男性患者之间的结局比较,重点关注30天死亡率和中期存活率.
主要成果:
- 女性患者 (27.7%) 呈现出更多的并发症和更高的外科手术风险 (EuroScore II 12.0% vs 10.0%).
- 女性的术后过程显示了更长的通风时间 (20.0小时 vs 16.0小时),ICU停留 (4.0d vs 3.0d) 和更高的新发性透析率 (20.3% vs 16.3%).
- 在女性中,中期存活率明显较低 (45.4%对56.1%;P<0.001),女性性别是中期死亡率的独立预测因素 (HR 1.2).
结论:
- 男性患者更频繁地接受IE的心脏手术.
- 与男性相比,女性患者的手术风险和早期术后发病率较高,但与男性相比,30天死亡率相似.
- 女性性别与IE手术治疗后的中期生存率明显较低有关.
更多相关视频
07:50An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
Published on: January 7, 2019
6.8K
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
8.5K
相关概念视频
01:26Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
01:25Endocarditis I: Introduction
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:18Endocarditis III: Medical Management
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
01:29Endocarditis IV: Nursing Management
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...