与性结肠炎相关的核心微生物组相关蛋白与细胞因子相互作用,对肠道细菌产生协同或对抗作用
Ting Zhang1,2, Hang Zhong1,2, Lu Lin3
1Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Meihua East Road, Zhuhai, Guangdong 519000, China.
The ISME journal
|July 29, 2024
概括
炎症性肠病 (IBD) 破坏宿主微生物蛋白相互作用,抑制有益细菌并改变肠道功能. 这项研究揭示了炎症蛋白如何影响IBD中的微生物群落.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),与被破坏的宿主微生物相互作用有关.
- 在IBD中,宿主和微生物群之间的蛋白质水平相互作用仍然不太清楚.
研究的目的:
- 在IBD中的蛋白质水平上阐明宿主-微生物组关联网络.
- 研究关键炎症蛋白在IBD期间对肠道细菌的影响.
主要方法:
- 耗尽辅助的元蛋白组学用于绘制宿主微生物组网络的地图.
- 蛋白质学和脂质学分析特定炎症蛋白 (S100A8,S100A9,IL-1β,IL-6,TNF-α) 对肠道细菌的影响.
- 在体外研究中,使用便衍生的群体和单个细菌物种.
主要成果:
- IBD宿主蛋白转向炎症和屏障破坏,抑制有益的微生物功能,如短链脂肪酸的生产.
- 炎症性蛋白质 (S100A8,S100A9,细胞因子) 抑制肠道细菌中的纯氨酸核酸生物合成.
- 特定的炎症蛋白质对细菌蛋白质有不同的影响,S100A8 / S100A9联合抑制Bifidobacterium adolescentis和改变Bacteroides vulgatus脂质.
结论:
- 炎症蛋白在IBD期间在塑造肠道微生物群中发挥着重要作用.
- 了解这些以蛋白质为中心的相互作用为IBD病原体和潜在的治疗点提供了见解.
- 该研究提供了IBD中宿主微生物分子相互作用的全面资源.
关键词:
S100a8a8a S100a8a8a S100a8a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a S100a8a8a8S100a9a9a9a9a9a S100a9a9a9a9a S100a9a9a9a S100a9a9a S100a9a9a9 S100a9a9a9 S100a9a9a9 S100a9a9a9 S100a9a9a9 S100a9a9a9 S100a9a9a9 S100a9a9a9 S100a9a9细胞因子 细胞因子我们的肠道微生物组.炎症性肠病是一种炎症性肠病.这里是metaproteomic的一个例子.相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
160
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
160
Irritable Bowel Syndrome I: Introduction
264
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
264
Inflammatory Bowel Disease IV: Pharmacological Management
124
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
124
Drugs for Treatment of Ulcerative Colitis in IBD
133
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
133
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
362
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
362
Chronic Bowel Disorders: Introduction
436
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
436


