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Updated: Jun 18, 2025

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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同义和非同义的代码子替代可以减轻对GroEL在折叠方面的依赖

Tali Haviv Reingewertz1, Miki Ben-Maimon1, Zohar Zafrir2

  • 1Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.

Protein science : a publication of the Protein Society
|July 29, 2024
PubMed
概括

研究人员确定了区分Escherichia coli GroEL/ES chaperonin系统基本蛋白质折叠客户的特征. 小鼠二叶酸减少酶 (mDHFR) 的突变减少了它对GroEL的依赖,揭示了对蛋白质折叠途径的洞察力.

关键词:
格罗埃尔 (GroEL) 是一个古老的城市.陪伴者是指陪伴者,也就是说陪伴者.codon 的使用情况蛋白质折叠 蛋白质的折叠随机突变发生的随机突变发生.

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