隐藏和明显的多种自身免疫在1型糖尿病中的患病率:系统性审查和元分析
Mariana Celis-Andrade1, Victoria Morales-González1, Manuel Rojas2
1Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad Del Rosario, Bogotá D.C., Colombia.
Diabetes & metabolic syndrome
|July 29, 2024
概括
这项研究显示,8.5%的1型糖尿病 (T1D) 患者有明显的多种自身免疫 (PolyA),而14.5%有潜在的PolyA. 对于患有T1D的人来说,建议定期对并发性自身免疫性疾病进行查,特别是随着年龄的增长.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 1型糖尿病 (T1D) 经常与多种自身免疫 (PolyA) 相关,但在T1D患者中PolyA的患病率和模式仍然不完全理解.
- 了解PolyA的范围对于全面的患者管理和早期干预策略至关重要.
研究的目的:
- 进行系统性审查和元分析,以确定被诊断为T1D的个体中潜在和明显PolyA的流行率.
- 分析影响T1D中PolyA患病率的地理分布和相关因素,如疾病持续时间.
主要方法:
- 在遵循PRISMA指南的基础上,对主要医疗数据库进行了系统的文献搜索.
- 数据提取和质量评估由两位研究人员独立进行.
- 使用随机效应模型计算了潜在和明显PolyA的聚合患病率,并分析了影响因素的元回归分析.
主要成果:
- 该元分析包括来自158篇文章的270,890名T1D患者.
- 露天PolyA患病率为8.50% (95% CI,6.77-10.62),在北美 (14.50%) 处于最高水平. 自免疫性甲状腺疾病很常见 (7.44%).
- 潜伏多亚的患病率为14.45% (95% CI,11.17-18.49),在亚洲和大洋洲最常见. 疾病持续时间与潜在和明显的PolyA.正相关.
结论:
- 这项全面的元分析提供了对T1D中PolyA的流行率的关键见解,强调了积极查的必要性.
- 患有T1D的个体应定期对并发性自身免疫性疾病进行评估,特别是随着年龄的增长,以促进早期诊断和管理.
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