美国老年人抑郁症与认知能力的关联:使用NHANES 2013-2014跨截面数据的二次分析
Lulu Yao1, Jingnian Ni2, Mingqing Wei2
1Beijing University of Chinese Medicine, Beijing, China, redlu1989@163.com.
European neurology
|July 29, 2024
概括
抑郁症与美国老年人的认知功能较差有关. 早期治疗抑郁症可能有助于保持认知健康,特别是在那些患者健康问卷-9分数较高的人群中.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 抑郁症是影响认知表现的已知因素.
- 社会人口统计学和临床因素对这种关联的影响需要进一步阐明.
- 老年人代表了认知健康研究的关键人口.
研究的目的:
- 调查老年人抑郁症状与认知表现之间的关联.
- 探索社会人口统计学和临床因素的潜在改变作用.
- 了解抑郁症严重程度和认知功能之间的剂量反应关系.
主要方法:
- 从2013-2014年国家健康和营养检查调查 (NHANES) 中对1433名老年人的横截面分析.
- 使用患者健康问卷-9 (PHQ-9) 发现的抑郁症得分≥10;认知表现不佳定义为综合得分<47.
- 使用后勤回归和受限立方线 (RCS) 分析,逐步调整混因子.
主要成果:
- 与非抑郁组 (14.1%) 相比,抑郁组 (36.6%) 的认知表现差的患病率显著更高.
- 在完全调整后,抑郁仍然与认知表现差 (aOR=2.25,95% CI:1.31-3.81) 有显著的关联.
- 在PHQ-9分数和认知表现之间观察到非线性,J形的关联,根据性别和教育水平进行修改.
结论:
- 抑郁症与美国老年人的认知表现不佳独立相关.
- 针对早期抑郁症识别和治疗的干预策略可能对保持认知健康至关重要.
- 非线性关系表明,较高的抑郁症严重程度对认知构成更大的风险.
更多相关视频
相关概念视频
01:30Cognitive Development During Adulthood
73
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
73
01:18Depression: Overview
230
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
230
01:30Negative and Cognitive Symptoms of Schizophrenia
47
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
47
01:30Stress and Mental Health
94
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
94
01:03Long-term Depression
2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.5K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
114
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
114