在患有自闭症谱系障碍的儿童中,内化问题,白质完整性和社会困难之间的关联
Yu Feng1, Xinyue Huang1, Weixin Zhao1
1The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China; MOE Key Lab for Neuro information, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, PR China.
概括
患有自闭症谱系障碍 (ASD) 的儿童表现出更多的内化问题,这些问题将社会困难与关键大脑电路中的白质完整性联系起来. 这突出了将内部化问题作为ASD中介者的作用.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿童精神病学 儿童精神病学
背景情况:
- 自闭症谱系障碍 (ASD) 呈现出社会缺陷和经常同时出现的内化和外化问题.
- 这些行为问题在ASD儿童中经常被低估.
- 白质完整性对大脑功能和发育至关重要.
研究的目的:
- 为了比较患有自闭症儿童和典型发育对照 (TDCs) 之间的白质完整性,特别是分数异构性 (FA).
- 探索社会困难,内化/外化问题和ASD儿童白质完整性之间的关系.
- 研究白质完整性与社会困难之间的关联中,内化问题的调解作用.
主要方法:
- 扩散张力成像 (DTI) 用于测量白质区域的分数异构性 (FA).
- 79名患有自闭症的儿童和70名年龄,性别和手性相匹配的TDC (年龄为3-7.8岁) 参与了这项研究.
- 统计分析包括组比较,相关性分析和调解分析.
主要成果:
- 患有自闭症的儿童表现出更高的内化和外化问题,与社会困难相关.
- 与TDC相比,在患有ASD的儿童中,前-部-部白质道中发现了降低的FA值.
- 在这些区域,较低的FA与内化问题和社会困难 (SRS-TOTAL分数) 有负相关性.
结论:
- 内化问题调解了白质完整性 (特别是L-MdLF和CCM) 与ASD儿童的社会困难之间的关系.
- 这些发现增强了对ASD行为和大脑结构之间的相互作用的理解.
- 针对内化问题可能是改善自闭症患者社会结果的关键治疗策略.
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