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Updated: Jun 18, 2025

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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Published on: August 14, 2019

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在工程化Saccharomyces cerevisiae中从简单糖中进行维拉生物合成

Peter H Winegar1, Graham A Hudson1, Luisa B Dell2

  • 1Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608, USA; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA; California Institute for Quantitative Biosciences (QB3 Institute), University of California, Berkeley, CA, 94720, USA.

Metabolic engineering
|July 29, 2024
PubMed
概括

研究人员对酵母进行了改造,以产生维拉,这是癌症药物候选人环胺的前体. 这种微生物生物合成的突破使得可扩展生产的类固醇化物用于药物开发.

关键词:
代谢工程是代谢工程.微生物生物合成自然产品是一种自然产品.这是一种类固醇类化合物.合成生物学 合成生物学维拉 (Verazine) 是一种维拉类药物.

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