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Updated: Jun 18, 2025

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由HLA-DQ8呈现的T细胞对本地和拼接自身抗原的交叉反应的结构基础

Mai T Tran1, Jia Jia Lim1, Tiing Jen Loh1

  • 1Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

The Journal of biological chemistry
|July 29, 2024
PubMed
概括

1型糖尿病中的T细胞受体对混合胰岛素 (HIP) 和本源胰岛素表位物进行交叉反应. 结构和突变研究揭示了驱动这种交叉反应性的关键残留物,为自身免疫性疾病机制提供了洞察力.

关键词:
T细胞受体的交叉反应性.在TCR-pMHC复合物中.第1类糖尿病患者.自体免疫性是一种自身免疫性.混合胰岛素 (HIP) 是一种混合胰岛素.主要组织相容性复合体 (MHC)

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