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生物催化剂可使生物基 furan 可扩展转化为各种furfurylamines

Pritam Giri¹, Seonga Lim¹, Taresh P Khobragade¹

¹Department of Systems Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.

Nature communications

|July 29, 2024

概括

研究人员开发了一种强大的转氨酶酶,用于高效,可扩展的生物基 furanaldehydes 的氨化. 这一突破使得基于的有价值化学物质可用于制药和聚合物的高性价比合成成为可能.

科学领域:

生物催化剂和绿色化学
有机合成有机合成
材料科学材料科学材料科学

背景情况:

生物基法兰是来自糖的有希望的可持续化学构建块.
在实现这些的选择性,高效和成本效益的可扩展转换方面仍然存在挑战.
甲的氨基化对于合成有价值的衍生物至关重要.

研究的目的:

为了识别和表征一个强大的转氨酶酶,用于可扩展的氨化.
阐明转氨酶改善活性的机制和结构基础.
开发酶级联过程,以合成关键的基于的化合物.

主要方法:

来自Shimia marina (SMTA) 的转氨酶的查和表征.
结晶学和突变性研究,以了解酶机制和增强活性.
酶级联和全细胞生物转化过程的发展.

主要成果:

SMTA 显示出高活性和广泛的基质特异性,用于生物基法兰胺氨化.
机械和结构见解使SMTA能够进行增强的基质转换.
一个一的酶级联成功地从5-基甲基中合成了2,5-bis-aminomethyl-furan (BAMF) 和5-aminomethyl-furan-2-carboxylic acid.
实现了BAMF的全细胞生物合成,展示了它的实际应用.

结论:

一种强大的转氨酶 (SMTA) 已被开发用于有效和可扩展的生物基 furan 的氨基化.
酶级联和全细胞过程为基化学品提供了可持续的途径.
这些进展促进了生物基法兰在药品和聚合物中的工业应用.

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