可修改的生活方式因素和COVID-19后多系统后果,住院和死亡的风险

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Updated: Jun 18, 2025

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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

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Yunhe Wang¹, Binbin Su², Marta Alcalde-Herraiz³

¹Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Nature communications

|July 29, 2024

概括

健康的生活方式显著降低了长期COVID-19并发症的风险,包括多系统后果,死亡和住院. 采用有利的生活方式因素是患者康复和公共卫生准备的关键.

科学领域:

公共卫生公共卫生
流行病学流行病学
生活方式医学医疗

背景情况:

后COVID并发症对患者和医疗保健系统构成重大负担.
确定有效的预防策略对于减轻这些长期影响至关重要.
可修改的生活方式因素是干预的有希望的目标.

研究的目的:

评估可修改的生活方式因素与COVID-19多系统后果,死亡和住院之间的关联.
确定有利的生活方式对降低COVID后不良结果风险的影响.
评估生活方式因素独立于感染前并发症的贡献.

主要方法:

使用Cox比例危险模型对英国生物库队列 (n=68,896) 的分析.
评估可修改的生活方式因素,包括吸烟,饮酒,BMI,体力活动,久坐时间,睡眠时间和饮食.
评估结果,如10个器官系统的多系统后续,死亡和住院.

主要成果:

良好的生活方式 (6-10个健康因素) 与不良的生活方式 (0-4个因素) 相比,多系统后果的风险降低了36%.
在心血管,代谢,呼吸道,精神健康和其他系统中观察到风险降低,独立于并发症的显著益处.
良好的生活方式还与COVID后死亡 (HR 0.59) 和住院 (HR 0.78) 的风险降低有关.

结论:

坚持健康的生活方式是缓解长期COVID-19并发症风险和严重性的关键策略.
生活方式干预可以显著降低多系统后果,死亡率和感染后住院率.
这些发现强调了改变生活方式对于提高疫情准备和患者治疗结果的重要性.

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