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Updated: Jun 18, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

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细胞命运决定由一个形态原-转录因子-染色质修饰器轴决定

Jin Ming1,2,3, Lihui Lin3,4, Jiajun Li1,2

  • 1Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.

Nature communications
|July 29, 2024
PubMed
概括

像SALL4这样的转录因子 (TF) 使用NuRD复合体来控制细胞命运. BMP4信号破坏了这种相互作用,将细胞引导到原始内皮 (PrE) 而不是多能性.

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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