老年抑郁症表-15的抑郁症患病率与使用个人参与者数据元分析对DSM进行结构化临床采访进行了比较
Marc Parsons1,2, Lu Qiu3, Brooke Levis3
1Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Scientific reports
|July 29, 2024
概括
老年抑郁症量表 (GDS-15) 截止值≥5显著高估了老年人抑郁症的患病率. 截止值≥8是更准确的,但显示出高异质性,强调了诊断采访的必要性.
科学领域:
- 老年精神病学是一门精神病学专业.
- 流行病学 流行病学
- 心理测量验证 心理测量验证
背景情况:
- 老年抑郁量表 (GDS-15) 经常用于估计老年人抑郁症的患病率,通常具有≥5.5的截止分数.
- 然而,GDS-15截止值是为了查准确度而设计的,而不是流行率估计.
- 这种做法可能会导致老年人群中不准确的患病率数据.
研究的目的:
- 将GDS-15 (≥5截止值) 估计的抑郁症患病率与诊断和统计手册 (SCID) 结构化临床面试 (SCID) 的诊断进行比较.
- 评估是否使用另一个GDS-15切断值可以提供更准确的流行率估计.
- 为了确定最佳的GDS-15切割值来估计老年人中主要抑郁症的流行率.
主要方法:
- 进行了对个体参与者数据的元分析.
- 用通用线性混合模型来估计聚合流行率.
- 分析了包括3602名参与者在内的14项研究的数据,将GDS-15得分与基于SCID的大型抑郁症诊断进行了比较.
主要成果:
- 在GDS-15≥5切割值中,综合患病率为34.2%,远高于SCID诊断的患病率14.8%.
- 一个GDS-15切线≥8提供了最接近SCID诊断的估计 (平均差异-0.3%),但具有相当大的预测间隔.
- 患病率估计的差异与研究或参与者特征无关,这表明在≥5的截止值下,存在一致的高估.
结论:
- 通常使用的GDS-15截止值≥5显著高估了老年人中主要抑郁症的患病率.
- 虽然GDS-15截止值≥8显示了更好的准确性,但高异质性限制了其在流行率估计中的实际实施.
- 经过验证的诊断面试仍然是准确评估这群人群中主要抑郁症患病率的黄金标准.
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