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人形机器人可以在软生物反应器中机械地施加压力给生长在软生物反应器中的人类细胞

Pierre-Alexis Mouthuy¹, Sarah Snelling², Rafael Hostettler³

¹Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, United Kingdom. pierre-alexis.mouthuy@ndorms.ox.ac.uk.

Communications engineering

|July 29, 2024

概括

人形机器人为组织工程提供了新的可能性,通过为细胞培养提供生理上相关的机械刺激. 本研究探讨了它们在为临床应用开发功能移植的用途.

科学领域:

生物医学工程生物医学工程
组织工程是组织工程.
机器人技术机器人技术机器人技术

背景情况:

机器人生物反应器已经使用了20多年,通过机械刺激来生长组织工程结构.
目前的方法在生产用于临床使用的功能移植时存在局限性.

研究的目的:

调查使用人形生物反应器用于组织工程的可行性.
探索生理学上相关的机械刺激对移植体发育的潜力.

主要方法:

设计了一个灵活的生物反应器室,与改造的肌肉骨 (MSK) 人形机器人肩膀关节兼容.
在腔室内培养纤维细胞,并将它们 subjected to physiological adduction-abduction movements.同时将它们 subjected to physiological adduction-abduction movements. 在腔室内培养纤维细胞,并将它们 subjected to physiological adduction-abduction movements. 在腔室内培养纤维细胞,并将它们 subjected to physiological adduction-abduction movements.
在14天的机械负荷后分析了细胞的转录组.

主要成果:

在生理机器人手臂运动下证明了成功的纤维细胞培养.
初步的转录组分析显示,由于加载模式,基因表达有显著的变化.
表明机械刺激会影响细胞行为.

结论:

人形生物反应器代表了先进组织工程的一个有希望的平台.
MSK人形机器人可以为组织工程和生物材料测试提供生物机械现实的环境.
进一步的研究可以加速工程组织的临床转化.

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