墨西哥人口的皮肤颜色相关变体和对血清25(OH) D度和维生素D缺乏症的相互作用影响
Berenice Rivera-Paredez1, Alberto Hidalgo-Bravo2, Priscilla López-Montoya3
1Centro de Investigación en Políticas, Población y Salud (CIPPS), Facultad de Medicina-Universidad Nacional Autónoma de México (UNAM), 04510, Mexico City, Mexico.
Scientific reports
|July 29, 2024
概括
影响皮肤色素的遗传变异与墨西哥人口中较低的维生素D水平有关. 基因相互作用对维生素D状况和缺乏症风险起着至关重要的作用.
科学领域:
- 人类遗传学 人类遗传学
- 营养生物化学 营养生物化学
- 人口健康 人口健康
背景情况:
- 皮肤色素与循环维生素D (VD) 水平相反相关.
- 控制皮肤颜色的遗传因素可能会影响维生素D缺乏 (VDD) 的风险.
- 了解这些遗传联系对于公共卫生至关重要,特别是在多样化的人口中.
研究的目的:
- 在墨西哥人口中调查与皮肤色素和VD水平相关的遗传变异之间的关联.
- 评估特定遗传多态性对维生素D缺乏 (VDD) 风险的影响.
- 探索潜在的基因对基因相互作用,影响静脉疾病状态.
主要方法:
- 从卫生工作者队列研究中对848名墨西哥人的横截面分析.
- 八个关键的基因变异的基因定型涉及到皮肤颜色 (例如,rs16891982,rs12203592,rs1042602,rs1126809,rs1800404,rs12913832,rs1426654,rs2240751) 的皮肤颜色.
- 通过自我报告和使用线性和逻辑回归的统计分析来评估皮肤色素,包括相互作用分析.
主要成果:
- 八种遗传变异被证实与皮肤色素有关.
- 包括rs1426654和rs224075在内的遗传风险得分与明显较低的静脉疾病水平相关 (p=0.025).
- 观察到显著的基因相互作用:rs2240751 × rs12203592 (p=0.021) 具有VD水平和rs2240751 × rs12913832 (p=0.0001) 具有VD风险.
结论:
- 影响皮肤色素的遗传变异与墨西哥人口中静脉疾病水平的降低有关.
- 基因-基因相互作用是评估遗传多态化对VD状态的影响时需要考虑的重要因素.
- 这些发现强调了遗传学,皮肤色素和维生素D代谢之间的复杂相互作用.
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