一个网络控制理论管道,用于研究结构连接组的动态
Linden Parkes1,2,3, Jason Z Kim4, Jennifer Stiso5
1Department of Psychiatry, Rutgers University, Piscataway, NJ, USA. linden.parkes@rutgers.edu.
Nature protocols
|July 29, 2024
概括
网络控制理论 (NCT) 提供了一种强大的方法来分析网络结构如何影响系统动态. 这项研究提出了将NCT应用于结构连接体的管道,帮助神经科学研究.
科学领域:
- 神经科学是一个神经科学.
- 网络科学 网络科学
- 系统生物学 系统生物学
背景情况:
- 网络控制理论 (NCT) 分析了网络拓如何影响系统动态.
- NCT预测外部控制信号以改变系统动态.
- 在神经科学中,NCT越来越多地用于研究行为和心理健康.
研究的目的:
- 为人类结构连接组应用NCT提供一个全面的管道.
- 详细说明计算控制能量和平均可控制性的方法.
- 通过Python软件包支持NCT应用程序.
主要方法:
- 对结构连接体的NCT的应用.
- 计算神经活动状态转换的控制能量.
- 计算系统控制能力的平均可控性.
- 将NCT输出与零网络模型进行比较.
主要成果:
- 一个经过验证的管道,用于NCT应用到结构连接器.
- 量化控制能量和平均可控制性的方法.
- 对零模型比较的建议.
结论:
- 提出的管道有助于研究大脑连接组拓和神经动力学.
- NCT是了解大脑功能,发育和心理健康的一个有价值的工具.
- Python 软件包提高了 NCT 实现的可访问性.
更多相关视频
17:06Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
26.2K
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
7.2K
相关概念视频
Assembly of Complex Microtubule Structures
1.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
1.8K
Neural Circuits
1.1K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.1K
Neuroplasticity
320
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
320
Protein Networks
3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
Neuron Structure
12.8K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
12.8K
Neuronal Communication
820
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
820
