种类选择和模型使用:重振人类发展研究
1Department of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge, CB2 3RH, UK. ndh12@cam.ac.uk.
Journal of the history of biology
|July 29, 2024
概括
人类胚胎研究在医学进步和竞争的复杂相互作用和依赖于像小鼠这样的模型生物的推动下,已经起了突出地位. 这一转变凸显了在发育生物学中物种选择的不断变化的政治.
科学领域:
- 发展生物学 发展生物学
- 生殖医学 生殖医学
- 遗传学 是一个遗传学.
背景情况:
- 从历史上看,模型生物体主导着生物研究,而人类研究往往被忽视.
- 在过去的60年里,人类胚胎研究经历了关注和忽视的周期.
- 最近的进展使人类胚胎研究成为几个科学领域的最前沿.
研究的目的:
- 分析影响生物研究中物种选择的政治因素,重点关注人类发展.
- 通过检查与模型生物的关系来解释最近人类胚胎研究的激增.
- 了解人类研究如何与模型系统竞争并依赖模型系统.
主要方法:
- 在发育生物学中对研究趋势和物种选择的历史分析.
- 检查生殖生物医学,体外受精和干细胞科学的影响.
- 评估模型生物 (如老鼠) 和新技术的作用.
主要成果:
- 人类胚胎研究已经从外围转移到发育生物学,生殖医学和遗传学的中心.
- 人类研究的兴趣增加与对模型生物的竞争和依赖有关.
- 医疗应用,特别是体外受精,为人类样本提供了至关重要的访问权限,并推动了对临床相关性的需求.
结论:
- 人类胚胎研究的复兴在很大程度上是由模型生物研究和基础设施的进步实现的.
- 有机体和干细胞衍生的胚胎状结构的发展促进了人类发育生物学的新领域.
- 人类研究在战略上与模型系统竞争并利用模型系统,展示了动态的相互依赖.
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