移植脏中的细胞癌:回顾性评估
Ruslan N Trushkin1, Teymur K Isaev1, Pavel E Medvedev1
1Department of Urology, Moscow City Clinical Hospital № 52 of Moscow Healthcare Department, Moscow, Russian Federation.
BMC nephrology
|July 29, 2024
概括
细胞癌 (RCC) 发生在0.95%的移植患者中. 腹腔镜切除是对这种癌症的安全和有效治疗方法,这种癌症来自捐赠组织,可以通过遗传学来确定.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 移植医学 移植医学
背景情况:
- 移植显著降低了末期慢性病患者的死亡率.
- 接受脏移植的人面临恶性瘤的风险增加了一倍,细胞癌 (RCC) 的发病率是普通人群的10-30倍.
- 移植受体中RCC的风险增加可能是由于免疫抑制疗法,对移植瘤的文献有限.
研究的目的:
- 为了确定移植脏中细胞癌 (RCC) 的发生率.
- 评估和提高移植中RCC治疗的疗效.
- 研究移植受体中RCC发展的病因学.
主要方法:
- 从2013年到2023年,对3270名移植患者的RCC发病率进行了回顾性分析.
- 在移植脏中对RCC并发症进行手术的评估.
- 在移植脏中进行RCC的组织学确认和遗传研究,以确定病因.
主要成果:
- 移植脏中RCC的发生率为0.95% (31例).
- 在28名患者中进行了腹腔镜切除,在2名患者中进行了射频切除,在1名患者中进行了移植切除.
- 腹腔镜切除在治疗移植脏癌症方面表现出有效性和安全性.
结论:
- 腹腔镜切除是对移植中RCC的安全有效治疗方法.
- 移植脏中的癌症起源于捐赠组织.
- 移植癌的透明细胞变体是一种基因决定的疾病.
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