为什么MASLD落后于MAFLD:对诊断标准的批判性分析 代谢功能障碍相关肝脏疾病的演变
Mohamed Alboraie1, Amna Subhan Butt2, Alejandro Piscoya3
1Department of Internal Medicine, Al-Azhar University, Cairo, Egypt.
概括
与代谢功能障碍相关的脂肪性肝病 (MAFLD) 标准提供了一个比较新的代谢功能障碍相关的脂肪性肝病 (MASLD) 标准更有效的诊断方法. 有证据表明,MAFLD的表现更好,突出了其在定义这些肝脏疾病中的实用性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 诊断标准的演变 发展
背景情况:
- 自20世纪80年代以来流行的非酒精性脂肪性肝病 (NAFLD) 与代谢功能障碍有关,导致严重的健康问题.
- 2020年转向与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 引入了强调代谢功能障碍的新诊断标准.
- 2023年关于代谢功能障碍相关的脂肪性肝病 (MASLD) 标准的提案提供了轻微的修改,但缺乏概念上的优势.
研究的目的:
- 探索MASLD标准有限成功背后的原因.
- 为了比较MAFLD和MASLD标准的诊断性能.
- 突出证据支持继续使用MAFLD来定义与代谢功能障碍相关的肝病.
主要方法:
- 对脂肪肝疾病不断变化的诊断标准的审查.
- 对新出现的证据进行分析,比较MAFLD和MASLD的表现.
- 探索MAFLD和MASLD的概念基础.
主要成果:
- 根据MASLD的标准,它没有比MAFLD提供显著的概念优势.
- 新出现的证据表明,MASLD标准的表现比MAFLD标准差.
- MAFLD标准提供了一个积极的诊断框架,强调代谢功能障碍.
结论:
- MAFLD标准在诊断与代谢功能障碍相关的脂肪肝疾病方面取得了重大进展.
- 马斯德标准没有证明其优越性,并且可能比马斯德低效.
- 根据目前的证据,MAFLD仍然是定义和诊断代谢功能障碍相关的脂肪肝疾病的首选框架.
相关概念视频
Overview of Lipid Metabolism
1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
Inborn Errors of Metabolism
150
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
150
Diabetes: Symptoms, Diagnosis, and Complications
521
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
521
Diseases of the Liver and Gallbladder
499
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
499
Pathophysiology of Diabetes
913
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
913
Diagnostic and Statistical Manual of Mental Disorders (DSM)
53
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
53


