相关实验视频
Updated: Jun 18, 2025
10:41
Germ Cell Transplantation and Testis Tissue Xenografting in Mice
Published on: February 6, 2012
29.7K
丸组织的冷保存可能会被考虑在男孩与cryptorchidism
Linn Salto Mamsen1, Simone Hildorf2, Elissavet Ntemou1
1Department of Gynaecology, Fertility, and Obstetrics, Laboratory of Reproductive Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen 2100, Denmark.
Asian journal of andrology
|July 30, 2024
概括
试管体组织冷保存 (TTC) 是可行的,以保持在前青春期男孩的密码性. 这项研究表明,在未成熟的丸组织中,生殖细胞的存在很高,支持TTC作为这些患者的关键选择.
科学领域:
- 生殖医学 生殖医学
- 儿科内分泌学 儿科内分泌学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 密码症会影响青春期前男孩的生育潜力.
- 早期的骨科切除并不能完全减轻未来不孕症的风险.
- 保护生育能力对受影响的个体至关重要.
研究的目的:
- 评估丸组织冷保存 (TTC) 的可行性,以保护患有密码症的青春期前男孩的生育能力.
- 为了评估未成熟的丸组织中生殖细胞的存在和荷尔蒙特征.
- 确定TTC作为预防措施的必要性.
主要方法:
- 从56名青春期前的男孩中收集了丸组织样本,这些男孩在奥基奥佩克西或后续手术期间患有密码性.
- 样品经过冷保存和病理分析,包括生殖细胞计数和暗色精子 (Ad) 的评估.
- 测量了荷尔蒙水平 (FSH,LH,抑制素B),以评估内分泌功能.
主要成果:
- 在98.0%的双边活检和100%的单边活检中检测到生殖细胞,每种子管的中位数为0.39.
- 暗色精子 (Ad) 在66.1%的患者中存在,但30.2%缺乏Ad,这表明潜在的淋巴腺素缺乏.
- 荷尔蒙水平显示FSH在0.69 U/L,LH在0.21 U/L,和乙在126 pg/mL.
结论:
- TTC是一种可行的生育保护方法,适用于患有密码症的青春期前男孩.
- 没有成熟的丸组织显示出具有保护生育能力的巨大潜力.
- 需要进一步的研究来完善用于识别高风险不育的男孩的预测方法.
相关概念视频
01:27Testes: Histology
791
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
The spermatogenic cells, responsible for producing sperm, are...
791
01:23Infertility in Males
256
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
256
01:19Testes: Gross Anatomy
1.8K
The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
1.8K