相关实验视频
Updated: Jun 18, 2025

12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
18.8K
日本 isCGM 用户的血糖指标 - 根据糖尿病类型和治疗方法进行分析
Wataru Ogawa1, Tatsuhiko Urakami2, Takashi Kadowaki3
1Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Journal of diabetes investigation
|July 30, 2024
概括
使用FreeStyle Libre (FSL) 间歇扫描连续血糖监测 (isCGM) 的1型和2型糖尿病的日本成年人显示出良好的血糖控制. 非胰岛素治疗的2型糖尿病患者在范围内的时间达到最高,而1型糖尿病患者的葡萄糖变异性更高.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 医疗器械 医疗器械
背景情况:
- 间歇扫描的持续血糖监测 (isCGM) 系统,如FreeStyle Libre (FSL),通过提供实时的血糖数据,有助于糖尿病自我管理.
- 虽然FSL的好处在全球范围内得到了记录,但针对日本成年糖尿病患者的具体数据有限.
研究的目的:
- 用FSL isCGM评估1型和2型糖尿病的大群日本成年人的血糖控制.
- 为了描述FSL在日本不同糖尿病治疗组的使用模式和结果.
主要方法:
- 对来自日本3463名FSL用户的匿名数据进行了回顾性分析.
- 划分为四组:1型糖尿病,2型糖尿病每日多次注射 (MDI),2型糖尿病只有基底胰岛素 (BOI) 和2型糖尿病非胰岛素治疗 (NIT).
- 使用已建立的持续葡萄糖监测 (CGM) 度量,包括葡萄糖变化和范围内的时间 (TIR) 的评估.
主要成果:
- 所有组均表现出一般良好的血糖控制.
- 1型糖尿病患者的葡萄糖变化率最高 (SD: 61 mg/dL,%CV: 40%),超过了≤36%的目标%CV.
- 2型糖尿病-NIT使用者实现了最高的平均%TIR (84.3%) 并最频繁地实现了TIR目标 (87.4%),而1型糖尿病使用者则具有最低的平均%TIR (62.6%) 和目标实现率 (30.5%).
结论:
- FSL isCGM为患者和医疗保健提供者提供了有效的血糖游览和历史葡萄糖模式的监测.
- 使用FSL时,血糖控制结果因不同类型的糖尿病和治疗方案而异.
- 进一步的研究可以优化FSL在日本不同患者群体的利用.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Diabetes: Management and Pharmacotherapy
250
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
250
Insulin: Dosing Regimen and Adverse Effects
163
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
163
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
168
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
168
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Dipeptidyl Peptidase 4 Inhibitors
180
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
180

