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探索厌食症与晚期肺癌治疗疗效之间的关系:一项回顾性研究
Kosei Doshita1, Tateaki Naito1, Suguru Matsuda1
1Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
晚期肺癌患者的化疗诱导的厌食症与显著的体重减轻和治疗效率降低有关. 支持性护理对于控制厌食症和改善基化疗与免疫检查点抑制剂期间的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 临床医学 临床医学
背景情况:
- 化疗诱导的厌食症在晚期肺癌中很普遍.
- 它对基于的化疗和免疫检查点抑制剂的结果的影响尚不清楚.
- 这项研究调查了第四阶段非小细胞肺癌患者的厌食症.
研究的目的:
- 探索化疗诱导的厌食症与治疗结果之间的关系.
- 评估患有厌食症的患者的体重减轻和治疗疗效.
- 评估厌食症对无进展和整体存活时间的影响.
主要方法:
- 对106名患有第四期非小细胞肺癌的患者进行了回顾性审查.
- 从2019年1月到2022年10月的数据分析.
- 厌食症,恶心和吐的评估使用常见术语对不良事件的标准v 5.0.0.
- 评估减肥和治疗疗效 (无进展和整体存活期).
主要成果:
- 化疗诱导的厌食症发生在13.2%的患者中.
- 厌食症组在治疗后6周和9周显著减肥.
- 在厌食症组中观察到较短的无进展和整体存活时间,尽管在统计学上并不显著.
结论:
- 化疗诱导的厌食症与显著的体重减轻和IV期非小细胞肺癌治疗效率的降低有关.
- 对厌食症的强有力的支持性护理对于减轻体重减轻至关重要.
- 有效的营养不良症管理可以帮助在用免疫检查点抑制剂的基化疗期间保持治疗有效性.
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