在患有帕金森病的人群中,前额叶皮层活动在行走过程中的变化的时间过程
Carla Silva-Batista1, William Liu1, Rodrigo Vitorio1,2
1Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Neurorehabilitation and neural repair
|July 30, 2024
概括
在帕金森病 (PD) 中,行走期间前额皮层 (PFC) 活动减少与更好的步态相关. 持续的PFC活动表明认知灵活性较差,步态受损.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 认知功能 认知功能
背景情况:
- 帕金森病 (PD) 通过将控制从自动性转移到前额叶皮层 (PFC) 的执行功能来改变步态.
- 在PD中行走期间PFC活动的时间模式及其与步态和临床因素的关系仍然不清楚.
研究的目的:
- 为了确定PD患者在行走期间PFC活动的时间进程.
- 探索是否临床或步态变量预测PFC活动的变化.
主要方法:
- 三十八个患有PD的个体 (停药) 使用功能近红外光谱 (fNIRS) 来测量行走期间的PFC活性.
- 可穿戴式传感器捕获了时空空间步态参数.
- 参与者根据PFC活动变化 (减少或持续) 从早期到晚期的行走阶段进行分组.
主要成果:
- 与持久PFC活动的人相比,PFC活动减少的个体表现出较少的步行障碍,包括更快的步行速度.
- 认知设置转移能力在持续活动组中占PFC激活变异的18%.
结论:
- 随着时间的推移,在PD行走期间PFC活动的减少与更好的步行表现有关.
- 持续的PFC活动与认知灵活性受损有关,并表明步行控制不太自动.
- 这些发现强调了PFC在帕金森病中对步态调节的动态参与.
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