纤维酸和末期病风险:一项全国性的队列研究
Young Youl Hyun1, Kyung-Soo Kim2, Sangmo Hong3
1Division of Nephorology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Diabetes, obesity & metabolism
|July 30, 2024
概括
在他类药物患者中使用费诺纤维酸可能会降低患末期病的风险. 这项研究表明它具有保护作用,特别是在高血压或功能下降的人群中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 众所周知,纤维酸改善功能标志物,如白色素尿和估计的膜过率.
- 类药物通常用于心血管风险管理.
研究的目的:
- 对已经接受了他类药物治疗的患者的费诺纤维酸使用与发展末期病 (ESRD) 的风险之间的关联进行调查.
- 在现实环境中评估费诺纤维酸的脏保护潜力.
主要方法:
- 在全国范围内,基于人口的队列研究使用2010年至2017年的数据进行.
- 413,715名费诺纤维素使用者与413,715名非费诺纤维素使用者 1:1匹配,来自较大的他类药物治疗人群.
- 事件末期病是主要的结局指标.
主要成果:
- 在3.96年的中位数随访期间,费诺纤维酸使用者的ESRD发病率显著降低 (0.885比0.960每1000人年).
- 费诺纤维酸使用与ESRD (0.763;95%CI:0.710-0.821) 的危险比率降低有关.
- 在高血压,蛋白尿或估计的球过率<60毫升/分钟/1.732的子组中,保护性关联显著.
结论:
- 在接受他类药物治疗的患者中,尤其是患有高血压,蛋白尿或功能下降的患者中,使用费诺纤维酸与发生末期病的风险较低有关.
- 需要进行进一步的随机对照试验,以证实费诺纤维酸在慢性脏疾病中具有脏保护功效.
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