呼吸抑制的程度根据作用点度在remimazolam的目标受控输注:一个随机对照试验
Soo Jung Park1, Sang Kee Min, Gyubin Choi
1From the Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, South Korea (SJP, SKM, GC, JEK, HYK).
雷米马拉姆输液可以导致呼吸抑制,特别是在更高度的情况下. 与较高剂量 (RMZ-1000,RMZ-1500) 相比,较低的雷米马佐拉姆度 (RMZ-500) 需要较少的呼吸支持.
科学领域:
- 麻醉学和药理学和药理学.
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 雷米马佐拉姆是一种短效的二,用于麻醉的诱导和维持.
- 虽然与普罗波福尔相比,雷米马佐拉姆与呼吸系统抑郁症的相关性较小,但雷米马佐拉姆本身具有呼吸系统妥协的风险.
研究的目的:
- 为了调查在雷米马佐拉姆输注期间呼吸抑制的发生率和严重程度.
- 为了评估不同目标效果场所度的雷米马佐拉姆对呼吸功能的影响,使用目标控制输液.
主要方法:
- 一项前性,双盲,随机对照性研究,涉及107名接受全身麻醉的患者.
- 患者被分配到三个组,接受500,1000或1500 ng/mL的雷米马佐拉姆度的目标效果部位度.
- 根据SpO2水平进行呼吸支 (下推力,氧气,辅助通风);呼吸变量和意识丧失被监测.
主要成果:
- 较高的雷米马索拉姆度 (1000和1500 ng/mL) 需要比500 ng/mL组 (P < 0.001) 需要更多的呼吸支持.
- 分别在RMZ-1000和RMZ-1500组的48.6%和50%的患者需要辅助呼吸,而在RMZ-500组只有2.8% (P<0.001).
- 在高度组的所有患者中,实现了意识丧失,而RMZ-500组的86.1% (P = 0.010). 在所有组中,潮体积下降,呼吸率显著增加.
结论:
- 雷米马佐拉姆输液会诱导剂量依赖的呼吸抑制,类似于其他二.
- 目标效应部位度较高的雷米扎拉姆与呼吸抑制和氧气脱的风险更高有关.
- 制定适当的对策对于管理在雷米马佐拉姆服药期间可能发生的氧气脱非常重要.
更多相关视频
04:56In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
Published on: October 23, 2018
08:49Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
相关概念视频
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Inhalational Anesthetics: Overview
CNS Depressants: Barbiturates and Benzodiazepines
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Parenteral Anesthetics: Overview
