新的生物标志物揭示了阿米奥达龙诱导的甲状腺功能障碍症中组织和血清甲状腺激素状态之间的不匹配
Richárd Sinkó1, Mónika Katkó2, Géza Tóth3
1Laboratory of Molecular Cell Metabolism, HUN-REN Institute of Experimental Medicine, Budapest 1083, Hungary.
The Journal of clinical endocrinology and metabolism
|July 30, 2024
概括
使用毛囊标记物的新方法评估了组织甲状腺激素 (TH) 的作用,揭示阿米奥达龙并不总是导致患者的组织甲状腺功能障碍. 这有助于在复杂的甲状腺病例中进行诊断.
科学领域:
- 内分泌学和新陈代谢学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 血清甲状腺激素和甲状腺激素 (TH) 水平是标准的甲状腺功能标志物.
- 他们的诊断实用性在像阿米奥达龙诱导的甲状腺功能增强症 (AIH) 这样的疾病中是有限的.
- 评估组织TH作用至关重要,但目前无法实现.
研究的目的:
- 开发一种评估组织TH作用的方法.
- 为了确定血清TH参数如何反映实际组织TH作用.
- 为了研究阿米奥达龙对组织TH作用的影响.
主要方法:
- 在人类毛囊 (HFs) 中使用下一代测序识别了TH-响应基因.
- 开发了一种基于HF标记物的分类模型,以评估组织TH作用.
- 在接受阿米奥达龙治疗的患者和小鼠模型 (THAI小鼠) 中验证了模型.
主要成果:
- 基于HF的分类模型准确地预测了组织TH状态.
- 血清和HFTH状态在euthyroid/hypothyroidamiodarone患者中对齐.
- 艾米奥达龙降低了甲状腺功能过高患者的一致性,表明AIH并不总是意味着组织甲状腺功能过高;这在THAI小鼠中得到证实.
结论:
- 一种微创性HF标记方法评估组织TH经济,帮助复杂的诊断.
- 很大一部分AIH患者没有表现出组织甲状腺功能障碍,这表明阿米奥达龙可以提供组织保护.
- 在AIH患者中评估组织TH作用是治疗决策的建议.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.4K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.4K
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
128
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
128
01:12Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
952
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
952
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
69
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
69