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老年人药物递送 - - 障碍,当前技术和未来道路
Emma A Kean1, Oluwatoyin A Adeleke1,2
1Preclinical Laboratory for Drug Delivery Innovations, College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.
Journal of drug targeting
|July 30, 2024
概括
老年患者因身体和认知障碍而面临药物输送挑战. 新型药物输送系统和个性化医疗对于提高老年人药物安全性和疗效至关重要.
科学领域:
- 老年人药理学 老年人药理学
- 药物输送系统 药物输送系统
- 生物医学工程 生物医学工程
背景情况:
- 全球医疗保健系统面临着老龄化人口日益增长的需求,其特点是慢性疾病和多药的高患病率.
- 老年患者在有效的药物输送方面遇到重大障碍,包括认知和身体功能变化,影响药物坚持和结果.
研究的目的:
- 审查慢性疾病和与年龄相关的药物动力学变化对老年人药物有效性和安全性的影响.
- 探索当前和新兴的药物输送技术,旨在克服老年患者面临的特定挑战.
- 确定研究缺口和老年药物配方开发的未来方向.
主要方法:
- 文献综述侧重于老年人的慢性疾病,药理动力学,药物给药途径和输送系统并发症.
- 分析传统和先进的药物输送技术,包括纳米药物,3D打印,3D打印,长效配方,透皮系统,口服分解片,以及味道/形状修饰.
- 在老年人群中识别药物输送障碍.
主要成果:
- 药物动力学与年龄相关的变化可以显著影响老年人药物的疗效和安全性.
- 现有的药物输送技术往往无法解决老年患者独特的认知和身体限制.
- 像纳米药物,3D打印和个性化医疗等新兴技术显示出改善老年人药物输送的前景.
结论:
- 在老年药物输送系统中优先考虑安全性,需要考虑与年龄相关的药物动力学变化,无毒辅助剂和副作用最小的药物.
- 新的方法,如3D打印,个性化医疗和长效配方,对于老年人药物输送的未来进步至关重要.
- 解决药丸负担和通过改变形状/尺寸来改善药物配方是未来研究的关键领域.
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