与老年人抗精神病药物使用相关的不良反应
Javeria Khalid1, Rajender R Aparasu
1Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston, Houston, Texas, USA.
Expert opinion on drug safety
|July 30, 2024
概括
抗精神病药物 (AP) 对老年人构成重大风险,包括死亡率,跌倒,心血管事件和感染. 谨慎的处方和监测至关重要,以减轻这种脆弱人群的不良影响.
科学领域:
- 老年人药理学 老年人药理学
- 精神病学不良事件 精神病学不良事件
- 现实世界的老龄化证据
背景情况:
- 抗精神病 (AP) 药物广泛用于各种疾病.
- 老年人特别容易受到APs显著的不良影响.
- 需要更新AP在老年人中的安全性.
研究的目的:
- 审查与老年人AP使用相关的不良事件的现实世界证据.
- 为此群体提供AP相关不良影响的最新概况.
- 为临床实践提供有关安全的AP处方的信息.
主要方法:
- 对AP相关不良事件的现实世界证据的审查.
- 检查特定风险,包括死亡率,跌倒,心血管事件和感染.
- 关于老年人AP安全性的专家意见综合.
主要成果:
- 典型的AP与较高的全因死亡率和额外amidal症状有关.
- 非典型的AP与跌倒/骨折以及诸如中风等心血管风险有关.
- 风险的VTE/PE和感染需要谨慎使用AP;关于糖尿病和AKI的证据是相互矛盾的.
结论:
- 抗精神病药物在老年人中存在多种不良事件风险.
- 谨慎的处方,剂量调整和警的监测至关重要.
- 需要进一步的实践研究来澄清风险,并为临床决策提供信息.
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