在COVID-19大流行期间的儿科涅马特里尔维尔/里托纳维尔处方模式
Seuli Bose-Brill1, Kathryn Hirabayashi2, Emmanuel Schwimmer1
1Combined Internal Medicine and Pediatrics Section, Division of General Internal Medicine, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, Ohio.
Hospital pediatrics
|July 30, 2024
概括
尼尔马特里尔维尔/里托纳维尔更常被处方给患有慢性疾病的儿科COVID-19患者,但仍然很少. 为了有效的临床决策,需要更多关于nirmatrelvir/ritonavir的儿科数据.
科学领域:
- 儿童传染病 儿童传染病
- 临床药理学 临床药理学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 儿童群体的冠状病毒病2019 (COVID-19) 管理需要了解治疗模式.
- 尼尔马特里尔维尔/里托纳维尔是一种用于COVID-19的抗病毒药物,但其在儿童中的使用需要进一步调查.
- 确定影响处方实践的因素对于优化治疗可访问性至关重要.
研究的目的:
- 为了确定与尼尔马特里尔维尔/里托纳维尔在COVID-19的儿科患者处方相关的人口和临床因素.
- 分析12-17岁青少年内尼马特里尔维尔/里托纳维尔使用的频率和预测因素.
- 为临床决策提供信息,并改善儿童对涅马特里尔维尔/里托纳维尔的使用.
主要方法:
- 使用PEDSnet.net电子健康记录数据进行的回顾性队列研究.
- 纳入标准:在2022年1月至2023年8月期间被诊断患有COVID-19的12-17岁患者.
- 多变量逻辑回归分析以确定尼马特里尔维尔/里托纳维尔处方的几率,并根据临床和人口因素进行调整.
主要成果:
- 总共分析了20959名COVID-19的儿科患者;408人接受了尼尔马特里尔维尔/里托纳维尔.
- 患有慢性或复杂慢性疾病的患者接受涅马特里尔维尔/里托纳维尔的几率更高 (分别为OR 2.50和2.21).
- 与非西班牙裔白人患者相比,西班牙裔患者接受涅马特雷尔维尔/里托纳维尔的几率较低 (OR 0.61).
结论:
- 患有慢性疾病的儿科患者更有可能接受针对COVID-19的nirmatrelvir/ritonavir,但处方仍然不常见.
- 对尼尔马特里尔维尔/里托纳维尔在儿童的安全性和有效性的进一步研究是必不可少的.
- 优化临床决策需要对尼尔马特里尔维尔/里托纳维尔对严重疾病和住院住院的影响有 robust 的儿科数据.
更多相关视频
相关概念视频
Prescription, Nonprescription and Orphan Drugs
711
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
711
Transmission-based Precautions I: Contact, Enteric, and Droplets
3.5K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
3.5K
Routes of Drug Administration: Parenteral
1.9K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.9K
Retrovirus Life Cycles
45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
Renal Failure: Dose Adjustments
77
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
77
Drug Dosage Regimen: Overview
3.5K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.5K


