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Updated: Jun 18, 2025

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells
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In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells

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希斯子β-基基化在逆转沙尔科佩尼亚方面至关重要

Qiquan Wang1, Xinqiang Lan1, Hao Ke1

  • 1Metabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.

Aging cell
|July 30, 2024
PubMed
概括

β-基酸盐 (β-HB) 通过通过基因组修饰来增强线粒体功能来逆转与年龄相关的肌肉损失 (肉类衰老). 这一发现为改善老年人群肌肉健康提供了一个新的治疗点.

关键词:
线粒体中的线粒体.这种类型的麻症是sarcopenia.这是骨肌肉的骨架肌肉.这是一种β-基酸盐.这是一种β-基基基化.

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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

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相关概念视频

Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Nucleosome Remodeling

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Nucleosome remodeling complex
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Histone Variants at the Centromere

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Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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