乳腺癌患者心血管死亡的相对风险:一个基于人口的研究
Chengshi Wang1,2, Tao He3, Zhu Wang2
1Department of Breast Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, 610044 Chengdu, Sichuan, China.
Reviews in cardiovascular medicine
|July 30, 2024
概括
乳腺癌患者面临心血管疾病 (CVD) 死亡率略高的风险. 这种风险在诊断后不久是最高的,特别是在年轻的幸存者中,强调了早期心血管疾病监测的必要性.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 乳腺癌幸存者除了癌症复发之外还有独特的健康风险.
- 心血管疾病 (CVD) 是癌症幸存者的重要关注点,可能受到癌症治疗和共同风险因素的影响.
研究的目的:
- 与一般女性人口相比,研究乳腺癌患者心血管疾病 (CVD) 死亡率的风险.
- 确定特定的时间框架和人口群体,在乳腺癌幸存者中增加心血管疾病死亡风险.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库的数据.
- 包括1990-2016年间诊断的924,439名女性乳腺癌患者,随访时间不到30年,与美国一般女性人口相比.
- 采用多变量波桑回归来计算心脏病死亡率的发病率比率 (IRR).
主要成果:
- 在30-64岁的乳腺癌患者中观察到心血管疾病死亡风险的轻微增加 (IRR 1.06).
- 风险在诊断后的第一个月内达到顶峰 (IRR为3.33),主要是由于心脏病 (IRR为1.11).
- 在30-34岁的幸存者中,最高的风险增加 (IRR为3.50) 被发现.
结论:
- 乳腺癌幸存者,特别是年轻的或具有侵略性瘤的患者,需要对心血管疾病死亡率进行警监测.
- 临床医生应在乳腺癌幸存者中实施心血管健康的风险减轻策略.
- 早期发现和管理心血管疾病风险因素对于改善这一群体的长期结果至关重要.
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