老年人使用静止剂对心血管疾病的初级预防:最新的系统性审查和元分析
Hao Huang1, Hechen Zhu2, Ru Ya1
1Department of Critical Rehabilitation, Shanghai Third Rehabilitation Hospital, 200436 Shanghai, China.
Reviews in cardiovascular medicine
|July 30, 2024
概括
静止剂的使用显著降低了65岁以上的个体心血管疾病 (CVD) 的风险. 这包括较低的全因死亡率,心血管疾病死亡率,心脏病发作,中风和总心血管事件的风险.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 预防医学 预防医学
背景情况:
- 在老年人中预防心血管疾病 (CVD) 需要更新的证据.
- 需要为临床实践提供有关该人口群体中他类药物使用的指导.
研究的目的:
- 综合关于使用他类药物在65岁及以上人群中预防心血管疾病的有效性证据.
- 为临床实践提供最新的指导.
主要方法:
- 观察性研究的系统审查和元分析,比较他类药物使用与不使用他类药物.
- 通过搜索PubMed,EMBASE,Cochrane图书馆和科学网络来确定研究.
- 主要结局包括全因死亡率,心血管疾病死亡率,冠心病 (CHD) /心肌梗塞 (MI),中风和总心血管事件.
主要成果:
- 包括12项观察性研究,涉及160多万参与者.
- 达丁类药物使用与所有原因死亡率 (46%),心血管疾病死亡率 (49%),心血管疾病/心肌梗塞 (17%),中风 (21%) 和总心血管事件 (25%) 的风险显著降低有关.
- 这些好处在各种年龄小组 (≥70,≥75,≥85岁) 和糖尿病和高血压患者群体中观察到.
结论:
- 类固醇药物治疗与老年人初级预防的死亡率和主要心血管事件的大幅降低有关.
- 这些发现支持在老年人中使用他类药物,包括那些患有糖尿病和高血压等并发症的人.
- 这些证据强化了他类药物在老年人群心血管疾病初级预防策略中的作用.
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