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使用微超声波检测前列腺癌的读者间协议:一个多机构研究

Steve R Zhou¹, Moon Hyung Choi^1,2,3, Sulaiman Vesal^1,2

¹Department of Urology, Stanford School of Medicine, Palo Alto, CA, USA.

European urology open science

|July 30, 2024

概括

微超声波 (MUS) 检测前列腺癌的读者间协议低于MRI. MUS对前列腺癌的敏感性有限,这表明其诊断性能目前不一致.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
医疗成像医学成像
在瘤学瘤学.

背景情况:

微超声波 (MUS) 为区分前列腺癌与正常组织提供了更高的分辨率.
初步研究表明,MUS的灵敏度与MRI相当,但用户的一致性需要评估.

研究的目的:

评估在解释微超声波 (MUS) 图像用于前列腺癌检测方面的读者间协议.
评估MUS解释在多位泌尿科医生与不同经验水平的一致性.

主要方法:

来自57名转诊前列腺活检的患者的MUS图像的未来收集.
来自四个机构的六名泌尿科医生对MUS图像的解释,对MRI和临床数据视而不见.
使用Light的 κ和正百分比协议 (PPA) 测量读者协议;二级结果是对等级组 (GG) ≥2前列腺癌的敏感性.

主要成果:

读者间一致性 (κ) 为0.30,正比一致性 (PPA) 为33%.
对于GG≥2前列腺癌的平均敏感度为0.66,但对于前部病变显著较低.
对于更高度的癌症 (GG ≥3) 观察到更高的一致性 (κ 0.41,PPA 45%) 和检测概率 (12x).

结论:

对MUS的病变位置的读者间一致性低于MRI之前报告的水平.
在前列腺中,MUS表现出缺乏检测前列腺癌的敏感性.
目前的MUS性能不一致性表明,它可能尚未取代前列腺癌诊断的MRI.

关键词:

读者之间的协议协议.微型超声波的使用方法前列腺癌是什么意思前列腺癌是什么意思有针对性的活检.

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