患有心房的患者肠道菌群的变化及其与心血管风险因素的相关性
Shi Chen1, Mingyue Tu1, Jiaran Shi2
1Department of General Practice, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan International Medical College, 310000 Hangzhou, Zhejiang, China.
心房 (AF) 患者表现出肠道微生物群组成的改变和减少的多样性,与C-反应蛋白 (CRP) 和左心室射出分数 (LVEF) 相关. 这些变化与AF严重性得分有所不同.
科学领域:
- 微生物学 微生物学
- 心脏病学 心脏病学
- 基因组学就是基因组学.
背景情况:
- 心房动 (AF) 与肠道微生物组的潜在变化有关.
- 研究这些变化可能会揭示有关AF病原和进展的新见解.
研究的目的:
- 使用16S rDNA测序分析AF患者的肠道菌群变化.
- 为了将这些变化与临床参数和AF严重程度得分相关联.
- 确定影响AF肠道微生物群变化的因素.
主要方法:
- 通过16S rRNA测序,比较了53名AF患者和29名健康对照者的肠道微生物组成.
- 测量了临床标志物,包括CRP,Hcy,TBA,BNP,Hs-cTn和LVEF.
- 分析了微生物群,临床数据和AF严重程度得分之间的相关性.
主要成果:
- 与对照组相比,AF患者的肠道菌群Alpha多样性减少.
- 观察到菌群,类,序列和家族层面的微生物组成有显著差异.
- 微生物群的变化与CRP和LVEF相关,并且在AF严重程度小组之间有所不同.
结论:
- 在AF患者中,肠道微生物群的组成和多样性发生变化.
- 这些变化与CRP和LVEF等特定的临床标志物有关.
- 肠道菌群的形状根据AF的严重程度而有所不同.
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