专蛋白校正的阴离子间隙与心脏性休克患者的死亡率之间的关联
Meng Yuan1, Lei Zhong1, Jie Min1
1Department of Intensive Care Unit, Huzhou Central Hospital (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University), Affiliated Central Hospital Huzhou University, 313000 Huzhou, Zhejiang, China.
蛋白校正的离子间隙 (ACAG) 是心脏性休克 (CS) 患者死亡率的独立预测指标. 入院时ACAG水平升高表明CS患者临床结果不佳和死亡率增加的风险更高.
科学领域:
- 关键护理医学 关键护理医学
- 临床化学 临床化学
- 流行病学 流行病学
背景情况:
- 心脏性休克 (CS) 是一种危及生命的疾病,死亡率高.
- 现有的CS死亡率生物标志物缺乏全面的研究.
- 蛋白校正的离子间隙 (ACAG) 在CS中没有得到广泛的研究.
研究的目的:
- 调查ACAG与CS患者死亡率之间的关联.
- 确定ACAG是否可以作为CS结果的预测标记.
主要方法:
- 使用了来自MIMIC-IV数据库 (v2.0) 的数据.
- 采用了卡普兰-梅尔曲线,日志级别测试,LASSO后勤分析和Cox比例危险模型.
- 通过ROC曲线评估预测能力,通过敏感性分析评估稳定性.
主要成果:
- 分析了839名CS患者,分为幸存者和非幸存者.
- 升高的ACAG与30日和90日生存率的下降显著相关 (p < 0.001).
- ACAG独立预测了CS患者30日和90天死亡率的增加 (p <0.05).
结论:
- ACAG是CS患者死亡的独立风险因素.
- ACAG预测CS的临床结果不佳.
- 在入院时ACAG升高 (特别是<20 mmol/L) 是CS患者全因死亡率的关键预测因素.
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