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麻症预测心力衰竭患者的不良预后:系统性审查和元分析
Yunyue Liu1, Mengyu Su1, Yang Lei1
1School of Nursing, Nanjing Medical University, 210000 Nanjing, Jiangsu, China.
Reviews in cardiovascular medicine
|July 30, 2024
概括
肌肉质量丧失的萨尔科佩尼亚与心力衰竭 (HF) 患者的死亡率增加和主要心血管不良事件有关. 诊断标准和研究区域影响这些不良预后预测.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 内部医学 内部医学
背景情况:
- 心力衰竭 (HF) 是一种复杂的疾病,与显著的发病率和死亡率有关.
- 标志着与年龄相关的骨肌肉质量和功能的损失的萨科佩尼亚,越来越多地被认为是HF的相关并发症.
- 在HF患者中,肉类的预后含义需要进一步阐明.
研究的目的:
- 评估萨科佩尼亚作为心力衰竭 (HF) 患者预后的预测指标.
- 调查不同诊断标准和地理区域对高频率患者肉类的预后结果的影响.
- 建立一个初步基础,用于早期识别和预测HF患者的恶性预后.
主要方法:
- 在PubMed,Cochrane,Embase和CNKI数据库中进行了系统的文献搜索,直到2023年3月.
- 包括评估HF患者肉症预后影响的队列研究,使用纽卡斯尔-太华尺度评估质量.
- 使用RevMan 5.3进行了元分析,并遵循系统性审查和元分析 (PRISMA) 准则的首选报告项目.
主要成果:
- 分析了12项研究,其中包括3696名高压患者.
- 与非sarcopenic患者相比,sarcopenic HF患者的全因死亡率 (HR = 1.98) 和主要不良心血管事件 (MACE) (HR = 1.24) 的风险明显更高.
- 小组分析表明,诊断标准和研究区域影响了死亡率预测,在不同地理区域和诊断工具中观察到差异,除了欧洲小组.
结论:
- 萨科佩尼亚是不良结果的重要预测因素,包括心力衰竭患者全因死亡率和MACE的增加.
- 诊断标准的异质性和研究环境的地理差异需要进一步验证这些预后发现.
- 这些结果强调了在HF患者的风险分层中考虑肉症的重要性,同时强调了对标准化诊断方法的需求.
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