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在过重或肥胖的青少年心血管风险的性别相关差异
Procolo Di Bonito1, Anna Di Sessa2, Maria Rosaria Licenziati3
1Department of Internal Medicine, "S. Maria delle Grazie" Hospital, 80078 Pozzuoli, Italy.
Reviews in cardiovascular medicine
|July 30, 2024
概括
与女孩相比,男孩的儿童肥胖与腹部脂肪,脂肪肝疾病以及心脏和血管问题的风险更大. 肥胖的青少年女孩面临更高的功能下降的风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 放射学 放射学是一门学科.
背景情况:
- 儿童肥胖是一个日益关注的问题,与心脏代谢疾病密切相关.
- 性别对青少年这些并发病的影响仍未得到充分研究.
- 了解性别特异性风险对于有针对性的干预至关重要.
研究的目的:
- 为了研究心脏代谢风险因素的性别相关差异.
- 评估超重/肥胖 (OW/OB) 青少年目标器官损伤的性别特异性临床前迹象.
主要方法:
- 对988名青少年 (10-18岁) 进行了横截面研究,这些青少年患有OW/OB.
- 进行了临床,生化和腹部超声波评估.
- 心声学 (LVM,RWT) 和带超声波 (cIMT) 数据被分组分析.
主要成果:
- 男孩表现出更高的腰与身高的比率 (WHtR),禁食葡萄糖,脂肪肝 (FLD),左心室质量 (LVM),相对壁厚 (RWT) 和动脉内心介质厚度 (cIMT).
- 女孩的估计球膜过率 (eGFR) 较低,轻度降低的eGFR (MReGFR) 患病率更高.
- 在糖尿病前期和高脂血症患病率方面没有发现任何显著的性别差异.
结论:
- 患有OW/OB的青少年男孩面临腹部脂肪,FLD和心脏/血管功能障碍的风险增加.
- 患有OW/OB的青少年女孩患有MReGFR的风险更高.
- 建议按性别分类风险分层来管理肥胖年轻人的心脏代谢风险因素和目标器官损伤.
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