阳石片改善了冠心病患者的运动能力:来自随机,双盲,安慰剂控制和多中心试验的结果
Sisi Zhang1, Yuqin Shen2, Peiliang Liu3
1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China.
Reviews in cardiovascular medicine
|July 30, 2024
概括
辛氏 (YXS) 片在患有冠状动脉心脏病 (CHD) 的患者中显著改善了运动能力. 然而,YXS在这个患者群体中没有显示对焦虑或抑郁症状的益处.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 冠心病 (CHD) 影响运动能力和精神健康.
- 传统治疗可能无法完全解决患者康复的各个方面.
- 研究新型治疗药物,如辛氏 (YXS) 片,至关重要.
研究的目的:
- 为了评估Yangxinshi (YXS) 片的临床有效性.
- 评估YXS对心脏病患者运动能力的影响.
- 确定YXS对心血管疾病患者焦虑和抑郁症状的影响.
主要方法:
- 一个随机,双盲,安慰剂控制的多中心临床试验.
- 包括82名被诊断患有冠心病的患者.
- 使用诸如峰值VO2,峰值MET,无氧值 (AT) 和6分钟步行测试 (6MWT) 等措施评估运动能力.
- 使用汉密尔顿焦虑评分表 (HAM-A) 和汉密尔顿抑郁评分表 (HAM-D) 评估焦虑和抑郁.
主要成果:
- 与安慰剂相比,YXS组在峰值VO2,峰值MET,AT VO2,AT MET和6MWT方面表现出显著的改善.
- 峰值VO2的差异为0.1L/分钟 (95%CI:0.04-0.16,p=0.000). 这是一个很大的差异.
- 6MWT显示平均差异为29.92米 (95%CI:18.78-41.07,p=0.000). 这是一个很大的差异.
- 在YXS和安慰剂组之间的HAM-A或HAM-D得分中没有发现显著差异.
结论:
- 辛氏 (YXS) 片可以提高冠心病患者的运动能力.
- 在这个人群中,YXS没有显示出减少焦虑或抑郁症症状的显著益处.
- 进一步的研究可能会探索YXS对运动能力最有利的特定机制和患者子组.
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