动脉硬指数与弗雷明汉心血管疾病风险评分的关联

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Lin Jin^1,2, LanYue Tong³, CuiQin Shen³

¹Department of Ultrasound, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, 201800 Shanghai, China.

Reviews in cardiovascular medicine

|July 30, 2024

概括

动脉硬度指数,动脉速度脉冲指数 (AVI) 和动脉压量指数 (API) 显示了与心血管疾病风险的U形联系. 这些发现可能会指导早期干预预防心脏病.

科学领域:

心血管生理学心血管生理学
心血管风险的生物标志物

背景情况:

动脉硬度指数,包括动脉速度脉冲指数 (AVI) 和动脉压量指数 (API),是心血管疾病 (CVD) 风险的公认指标.
了解这些非侵入性标志物与心血管疾病风险之间的准确关系对于早期检测和预防策略至关重要.

研究的目的:

调查动脉速度脉冲指数 (AVI) 和动脉压体积指数 (API) 以及弗雷明翰心血管疾病风险评分 (FCVRS) 之间的剂量反应关联.
探索关键动脉硬度指数与整体心血管疾病风险之间的非线性关系.

主要方法:

来自18岁及以上,记录有动脉硬度指数的个人队列的数据分析.
利用皮尔森的相关系数和多变量线性分析来评估关联.
使用受限立方线回归来建模AVI,API和FCVRS之间的非线性"剂量反应"关系.

主要成果:

在受限立方线模型中,观察到AVI和API与FCVRS之间存在显著的U形关联.
最低的心血管疾病风险得分与AVI约为8个单位和API约为18个单位有关.
在AVI超过12个单位 (达到27个单位左右) 和API超过23个单位 (在52个单位后平整) 后,FCVRS升高显示出快速增长.

结论:

动脉速度脉冲指数 (AVI) 和动脉压力体积指数 (API) 与弗雷明翰心血管疾病风险评分 (FCVRS) 呈现U形关联.
这些发现为动脉硬和心血管风险之间的复杂关系提供了新的见解.
鉴定到的关联可以为预防心血管疾病提供有针对性的早期治疗和改变生活方式的策略.

关键词:

弗雷明汉姆的成绩是什么动脉压力体积指数动脉硬性动脉硬性动脉速度脉冲指数动脉速度指数

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