评估心肌应变和心肌工作作为高血压心脏病的标记:一个元分析
1Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Reviews in cardiovascular medicine
|July 30, 2024
概括
高血压显著降低全球纵向应变 (GLS) 和全球周长应变 (GCS),同时增加全球辐射应变 (GRS). 这些心肌张力变化,以及心肌工作指数的改变,是高血压心脏病的早期指标,独立于左心室缩.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 高血压研究 高血压研究
背景情况:
- 高血压是一种常见的疾病,与心血管并发症有关.
- 左心室缩 (LVH) 是持续高血压的常见后果.
- 高血压对心肌压力和工作的影响,独立于LVH,需要进一步阐明.
研究的目的:
- 研究高血压患者心肌张力和心肌功能的变化.
- 为了确定心肌压变化在高血压中是否独立于LVH.
- 为了识别高血压心脏病的潜在早期标志物.
主要方法:
- 对Medline和EMBASE数据库进行了系统的文献搜索.
- 确定了在高血压患者中报告左心室应变和心肌工作的研究.
- 出版偏差是使用漏斗图和修剪和填充分析来评估的.
主要成果:
- 全球纵向应变 (GLS) 和全球周边应变 (GCS) 在高血压患者中显著降低.
- 全球辐射菌株 (GRS) 显示高血压显著增加,尽管有变化.
- 全球心肌工作指数 (GWI),建设性工作 (GCW) 和浪费工作 (GWW) 增加,而高血压的全球工作效率 (GWE) 降低.
- 降低高血压的GLS不依赖于LVH,但当LVH存在时进一步降低.
结论:
- 高血压与GLS和GCS的显著减少,以及GRS的增加有关.
- 心肌张力和工作指数在高血压中发生变化,这表明早期的心脏变化.
- 这些发现支持使用GLS和全球工作指数作为高血压心脏病的早期标志物.
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