在接受口服抗凝剂的心房患者中性别差异
Jo-Nan Liao1,2,3, Yu-Shan Huang1,2, Chuan-Tsai Tsai1,2
1Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, 11217 Taipei, Taiwan.
性别影响心房动 (AF) 风险,中风和口服抗凝剂 (OAC) 的有效性. 非维生素K对抗剂口服抗凝剂 (NOACs) 改善了两性结局,女性显示出更大的中风风险降低.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性别是心房动 (AF) 相关的缺血性中风的已知危险因素.
- 性别对口服抗凝剂 (OAC) 使用和患者预后的影响尚不清楚.
研究的目的:
- 调查AF患者中OAC使用和结果的性别特异性差异.
- 为了比较非维生素K对抗剂口服抗凝剂 (NOACs) 与华法林在男性和女性AF患者的有效性.
主要方法:
- 一项使用台湾国家健康保险研究数据库 (2012-2018) 的全国性队列研究.
- 包括67,426名使用OAC的AF患者,分析死亡,中风和出血等终点.
- 华法林和NOAC之间的结果比较,根据性别对子组进行分析.
主要成果:
- 女性AF患者年龄较大,风险得分较高 (CHA2DS2-VASc,HAS-BLED).
- 在女性中,NOAC的使用更为常见;在两性之间,华法林的使用情况相似.
- 与华法林相比,NOACs在两性中都降低了临床终点风险,女性缺血性中风风险的降低明显更大 (相互作用p=0.040).
结论:
- 在AF患者特征,风险概况和OAC利用方面存在显著的基于性别的差异.
- 与华法林相比,NOAC在男性和女性AF患者中显示出更好的临床结果.
- 患有AF的女性患者在预防缺血性中风方面从NOAC中获得更明显的益处.
更多相关视频
28:13Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
08:10Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
相关概念视频
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Factors Affecting Drug Response: Overview
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
