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Updated: Jun 18, 2025

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major
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附件1/FPR轴在莱什曼病外体介导的大莱什曼病皮肤过致病原发生过程中的影响

Alonso da Silva Lira Filho1,2, Andrea Lafleur1,2, Fernando Alvarez1,2

  • 1Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.

Frontiers in immunology
|July 30, 2024
PubMed
概括

莱什曼尼亚外基因组 (LeishEXO) 使用Annexin A1 (ANXA1) 和其受体 (FPR1/2) 通过促进寄生虫内部化来驱动莱什曼尼亚病原体. 阻断这个轴会抑制感染,提供治疗潜力.

关键词:
附录A1 附录 A1 是一个附录.这是FPR2的FPR2.莱什曼尼亚 (Leishmania) 是一种病.皮肤上的莱什曼病.外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.

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