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SARS-CoV-2 聚合酶连锁反应周期值趋势在免疫受损患者和隔离预防措施的影响

Courtney E Harris¹, Vineeta Vaidya², Zhou Lan³

¹Division of Infectious Disease, Medical University of South Carolina, Charleston, South Carolina, USA.

Open forum infectious diseases

|July 30, 2024

概括

与固体瘤患者相比,免疫功能低下的血液恶性瘤患者,特别是接受特定治疗的患者,在较长时间内释放SARS-CoV-2. 这一发现对于理解免疫受损个体的长时间病毒分泌至关重要.

科学领域:

传染性疾病传染性疾病
血液学血液学血液学
在瘤学瘤学.

背景情况:

免疫功能低下的患者面临更高的SARS-CoV-2感染严重后果的风险.
了解病毒分泌动态对于脆弱人群的感染控制和治疗策略至关重要.

研究的目的:

为了研究不同恶性瘤类型的免疫受损患者中SARS-CoV-2脱落的持续时间.
为了确定与长时间的病毒分泌相关的特定疗法.

主要方法:

对495名患有SARS-CoV-2感染的免疫功能低下患者的回顾性分析.
在感染后的20天内监测聚合酶连锁反应 (PCR) 周期值 (CT).
在患有血液性恶性瘤和固体器官恶性瘤的患者之间比较病毒分泌时间.

主要成果:

患有血液性恶性瘤的患者显示PCRCT值<33超过20天 (26%) 的频率高于患有固体器官恶性瘤的患者 (5%).
这种长时间的分泌特别在接受B细胞消耗疗法或布鲁顿氨酸激酶抑制剂治疗的患者中被注意到.

结论:

血液恶性瘤,特别是特定的向疗法,与免疫功能低下的患者的长期SARS-CoV-2脱落有关.
这些发现凸显了针对这些患者进行量身定制的感染控制措施和扩大监测的必要性.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.循环门值是指一个周期的门值.免疫性受损的人.感染控制的方法

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