牙科局部麻醉剂对反应性氧物种的影响:一个体外研究
Hidetaka Kuroda1, Shota Tsukimoto1, Azuma Kosai2
1Department of Dental Anesthesiology, Kanagawa Dental University, Kanagawa, JPN.
Cureus
|July 30, 2024
概括
牙科局部麻醉剂,如利多卡因和普罗卡因,可以清除有害的活性氧物种 (ROS),可能减少牙科治疗中的氧化应激. 阿尔蒂卡因显示出有限的ROS清理效应.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 牙科研究 牙科研究
背景情况:
- 氧化应激,反应性氧物种 (ROS) 和抗氧化防御之间的不平衡,与许多牙科疾病有关.
- 牙科局部麻醉剂被广泛使用,它们的潜在抗氧化特性可能有利于牙科实践.
研究的目的:
- 评估利多卡因,普里洛卡因和阿尔蒂卡因的活性氧物种 (ROS) 清除能力.
- 具体评估它们对基基 (HO•) 和超氧化离子 (O2•−) 的影响.
主要方法:
- 使用了电子自旋共振 (ESR) 旋陷技术.
- 对局部麻醉剂不同度的ROS清理活动进行了测量.
主要成果:
- 利多卡因,普里洛卡因和阿尔蒂卡因已经证明了依赖度的氧基 (HO•) 清除.
- 利多卡因和普罗洛卡因表现出度依赖的超氧化离子 (O2•−) 清除,而阿尔蒂卡因则没有.
- 对HO•清理的IC50值为0.029% (利多卡因),0.019% (普里洛卡因) 和0.014% (阿尔蒂卡因).
- 对O2•−清除的IC50值为0.033% (利多卡因) 和0.057% (普里洛卡因).
结论:
- 牙局部麻醉剂可能通过直接ROS清理提供保护作用,防止氧化和炎症损伤.
- 需要进一步研究以了解这些麻醉剂的抗氧化机制及其对氧化压力相关牙科疾病的临床影响.
关键词:
抗氧化作用具有抗氧化作用.在Articaine,我们可以看到Articaine.一个基基的氧基.利多卡因 (Lidocaine) 是一种药物.氧化应激是一种氧化应激.普罗罗卡因 (prilocaine) 是一种可怕的药物.有活性氧物种的反应性氧物种.这是一种超氧化离子.更多相关视频
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