循环神经素作为心血管疾病的新生物标志物
Jin-Xiu Lyu1, Dan-Dan Guo1,2, Yu-Chen Song1,2
1Department of Pharmacy, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, 225001 Yangzhou, Jiangsu, China.
Reviews in cardiovascular medicine
|July 30, 2024
概括
在运动期间由肌肉释放的myokines与心血管疾病 (CVD) 有关. 本综述探讨了它们在各种心脏病中的作用,以及它们作为未来生物标志物的潜力.
科学领域:
- 运动生理学 运动生理学
- 心血管医学 心血管医学
- 分子生物学分子生物学
背景情况:
- 肌基因是身体活动期间从骨肌肉中释放的蛋白质.
- 新出现的证据将肌与心血管疾病 (CVD) 的发展和进展联系起来.
- 在心血管疾病的不同阶段,特定的肌细胞因子在周围血液中显示出改变的水平.
研究的目的:
- 在各种心血管疾病中审查关键肌肉素 (肌肉素,虹膜素,BDNF,MG53,Meteorin-like,apelin) 的作用.
- 讨论这些肌和目前心血管疾病的临床生物标志物之间的关联.
- 探索myokines作为CVD的新型诊断和预后生物标志物的潜力.
主要方法:
- 综合性文献综述研究的研究调查myokines和心血管疾病.
- 对特定肌素的研究分析,包括肌素,虹膜素,BDNF,MG53,Meteorin-like和apelin.
- 检查myokine水平和已确定的心血管疾病生物标志物之间的关系.
主要成果:
- 肌基因在心肌梗塞,心力衰竭,动脉样硬化,高血压和糖尿病中起着重要的作用.
- 在不同心血管疾病阶段观察到肌胺度的动态变化.
- 确定了某些肌动素与现有的临床生物标志物之间的关联.
结论:
- 肌代表了理解和潜在治疗心血管疾病的一个有前途的领域.
- 需要进行进一步的研究,以克服将菌发现转化为临床实践的挑战.
- 菌具有作为CVD诊断,预后和治疗监测的新生物标志物的潜力.
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